Determination of the Component Fatty Acids of Human Forearm Sebum by Gas-liquid Chromatography* by A. T. James
نویسندگان
چکیده
1. Indene has been administered to rabbits by stomach tube, and fractionation of ether extracts of the urine has yielded optically active c8and tran8-indane-1:2-diol in a total amount corresponding to about 5% of the dose. Acid treatment of the urine, either before or after ether extraction, yielded indan-2-one in amounts corresponding to about 25% of the dose of indene. 2. The same two diols have been isolated from the urine of rabbits dosed with indene by subcutaneous injection. 3. c8-Indane-1:2-diol has been isolated from ether extracts of the urine of rats dosed with indene by stomach tube. Indan-2-one has been obtained by acid treatment of the extracted urine. 4. The interconversion of cisand tran8-indane1:2-diol has been studied, and the metabolic formation of the two diols is discussed.
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